Fig. 7.

Model of cortical development in U11 cKO mice. (A) Schematic representing cortical development in wild-type and mutant embryos, from E12 to E14. Black arrows show type of cell division; arrow thickness denotes relative frequency of that division. Question marks and dashed lines indicate events that remain to be explored. (B) Schematic of proliferating RGCs progressing through the cell cycle in the late E11/early E12 pallium. Arrow color denotes the presence (blue) or absence (black) of U11. MIGs with significantly elevated minor intron retention, and with known functions at specific cell cycle phases, are listed in boxes. Ana., anaphase; Cyt., cytokinesis; Met., metaphase; Pro., prophase; Tel., telophase. See also Table S5.