Table 2: Risk Factors for Torsade de Pointes and Brugada Syndrome by Antidepressant and Antipsychotic Drugs.

Risk Factor	Increased Risk for TdP	Increased Risk for BrS
Sex	Female	Male
Bradycardia	+	+
Hypokalemia	+	-/+
Hypomagnesaemia	+	-
Drug interaction (QT-prolonging agents)	+	-
Drug interaction (sodium or calcium channel blockers, parasympathetic agonists)	-	+
Drug interaction (slow metabolism by CYP inhibitors 2D6,1A2,3A4)	+	+
Hepatic dysfunction (increased drug concentration)	+	+
Genetic predisposition	Congenital LQTS	Congenital BrS

TdP: torsade de pointes; BrS: Brugada syndrome; CYP: cytochrome 450; LQTS: long QT syndrome.