Table 3: Drugs that Induce Brugada ECG Pattern (Type 1 ST-Segment Elevation) and that Should be Avoided in Patients with Brugada Syndrome.

	Drug	Class	Clinical use	References
Antidepressants
Tricyclic Antidepressant	Amitriptyline	IIA	Depression	85, 87
	Desipramine	IIA	Depression	70, 86
	Nortriptyline	IIA	Depression	72, 88
	Clomipramine	IIA	Depression/ obsessive compulsive disorder
	Imipramine	IIA	Depression/ anxiety
Tetracyclic Antidepressant	Maprotiline	IIA	Depression/ anxiety	87
Others	Lithium	IIB	Depression	82
	Bupropion Cyamemazine Dosulepin Doxepin Fluoxetin Fluvoxamine Maprotiline Paroxetine Lamotrigine	IIB	Depression Depression Depression Depression Depression Depression Depression Depression Depression Epilepsy, bipolar disorder	143
Antipsychotics	Trifluoperazine IIA	IIA	Anxiety, psychotic disorders	85
	Loxapine	IIA	Psychotic conditions including hallucinations, delusions, and confusion	144
	Clotiapine Cyamemazine Thioridazine	IIB	Psychotic disorders
Antiepileptic	Propofol	IIA	Sedative, hypnotic and antiepileptic	83, 84

Recommendation class: Class I: There is evidence and/or general agreement that a given drug is potentially arrhythmic in BrS patients. Class IIA: There is conflicting evidence and/or divergence of opinion about the drug, but the weight of evidence/opinion is in favour of a potentially arrhythmic effect in BrS patients. Class IIB: There is conflicting evidence and/or divergence of opinion about the drug, and the potential arrhythmic effect in BrS patients is less well established by evidence/opinion. BrS = Brugada syndrome. Source: Modified from www.brugadadrugs.org.