Table 4: IC50 Values for Block of IKr, ICa and INa by Antidepressant and Antipsychotic Drugs.
| Drug | IKr IC50(μM) | ICa IC50(μM) | INa IC50(μM) | References |
|---|---|---|---|---|
| Antidepressants | ||||
| Amitriptyline* | 4.78 | 3.75 | >1.0 | 92, 145–148 |
| Imipramine* | 3.4 | 4.0 | 5.0 | 92, 147, 149 |
| Fluoxetine* | 1.5–3.1 | 2.8 | 92, 147, 150, 151 | |
| Citalopram | 3.97 | 92 | ||
| Antipsychotics | ||||
| Chlorpromazine | 1.47 ± 0.03 | 152, 153 | ||
| Clozapine | 2.63 ± 0.12 | 152, 153 | ||
| Haloperidol | 1.0 | 154 | ||
| Sertindole† | 2.9 | 154 | ||
| Thioridazine | 1.07 ± 0.06 | 152, 153 |
*Drugs with mixed ion channel block[92]. † Drug withdrawn.