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. 2018 Sep 11;9:1028. doi: 10.3389/fphar.2018.01028

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Copyright © 2018 Zhang, Tang, Liu, Song, Peng, Zhu, Ouyang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Non-toxic Hes attenuated RANKL-induced osteoclast formation and function in vitro. (A) Cell viability of osteoclast precursors after Hes treatments for 24 h. (B) Linear correlation between OD values and cell numbers. (C) RANKL-induced osteoclastogenesis after Hes treatments in three types of preosteoclasts, RAW 264.7 cells, splenocytes, and BMMs. (D) Formation of RANKL-induced F-actin rings after Hes treatments. (E) Formation of RANKL-stimulated bone resorption pits after Hes treatments. ^∗p < 0.05 compared with controls, ^∗∗p < 0.01 compared with controls.