Table I.
Gene | Gene product | Function | Tumor site (OSCC/OPSCC) | (Refs.) |
---|---|---|---|---|
CCNA1 | Cyclin A1 | Cell cycle regulation | OSCC and OPSCC | (62,99) |
DAPK1 | Death-associated protein kinase 1 | Apoptosis and autophagy | OSCC and OPSCC | (62,63,99) |
DCC | Deleted in colorectal carcinoma | Netrin 1 receptor | OSCC | (62,100) |
EDNRB | Endothelin receptor type B | G protein-coupled receptor | OSCC | (62,100) |
ERCC1 | Excision repair cross-complementation group 1 | Repair of DNA damage induced by ultraviolet light or cisplatin | OSCC and OPSCC | (62,101) |
HOXA9 | Homeobox protein Hox-A9 | Gene expression, morphogenesis and differentiation | OSCC | (62,101) |
KIF1A | Kinesin family member 1A | Membranous organelle transportation along axonal microtubules | OSCC | (62,102,103) |
MED15 | Mediator of RNA polymerase II transcription subunit 15 | Transcriptional coactivator in RNA polymerase II transcription | OSCC | (62,104) |
MINT31 | Spen family transcriptional repressor family transcriptional repressor | Calcium channel regulator | OSCC | (62,99,105) |
NID2 | Nidogen-2 | Cell adhesion | OSCC | (62,102) |
PAXI | Paxillin | Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix | OSCC | (62,106) |
p16INK2A | p16 (also known as cyclin-dependent kinase inhibitor 2A) | Tumor suppressor gene | OSCC | (62,63,99) |
RASSF1α | Ras association domain family member 1 α | Growth inhibition along the RAS-activated signaling pathway | OSCC | (62,63) |
TIMP3 | Metalloproteinase inhibitor 3 | Inhibitor of the matrix metalloproteinases | OSCC and OPSCC | (62,99,105,107) |
OSCC, oral squamous cell carcinoma; OPSCC, oropharyngeal squamous cell carcinoma.