Table I.
GO enrichment analysis of the differentially expressed genes.
| Category | Term | Count | P-value |
|---|---|---|---|
| Upregulated genes | |||
| GOTERM_CC_DIRECT | GO:0005615 extracellular space | 43 | 5.44×10−15 |
| GOTERM_CC_DIRECT | GO:0070062 extracellular exosome | 62 | 1.09×10−14 |
| GOTERM_CC_DIRECT | GO:0005576 extracellular region | 40 | 1.61×10−10 |
| GOTERM_CC_DIRECT | GO:0005578 proteinaceous extracellular matrix | 15 | 3.09×10−8 |
| GOTERM_BP_DIRECT | GO:0022617 extracellular matrix disassembly | 9 | 2.36×10−7 |
| GOTERM_CC_DIRECT | GO:0031012 extracellular matrix | 14 | 7.17×10−7 |
| GOTERM_CC_DIRECT | GO:0016324 apical plasma membrane | 13 | 3.74×10−6 |
| GOTERM_BP_DIRECT | GO:0030198 extracellular matrix organization | 11 | 6.13×10−6 |
| GOTERM_CC_DIRECT | GO:0005796 Golgi lumen | 8 | 1.15×10−5 |
| GOTERM_BP_DIRECT | GO:0030574 collagen catabolic process | 7 | 1.58×10−5 |
| Downregulated genes | |||
| GOTERM_BP_DIRECT | GO:0008544 epidermis development | 22 | 3.26×10−22 |
| GOTERM_BP_DIRECT | GO:0030216 keratinocyte differentiation | 20 | 2.62×10−20 |
| GOTERM_CC_DIRECT | GO:0001533 cornified envelope | 15 | 1.04×10−16 |
| GOTERM_BP_DIRECT | GO:0018149 peptide cross-linking | 14 | 1.69×10−14 |
| GOTERM_BP_DIRECT | GO:0031424 keratinization | 13 | 2.97×10−13 |
| GOTERM_MF_DIRECT | GO:0005198 structural molecule activity | 21 | 7.55×10−12 |
| GOTERM_CC_DIRECT | GO:0070062 extracellular exosome | 74 | 8.36×10−12 |
| GOTERM_CC_DIRECT | GO:0030057 desmosome | 8 | 8.15×10−9 |
| GOTERM_MF_DIRECT | GO:0004867 serine-type endopeptidase inhibitor activity | 10 | 1.66×10−6 |
| GOTERM_BP_DIRECT | GO:0061436 establishment of skin barrier | 6 | 1.76×10−6 |
GO, gene ontology; _BP, biological process; _CC, cellular component; _MF, molecular function.