Table III.
GO and KEGG enrichment analyses of the differentially expressed genes in the modules.
| Category | Term | Count | P-value |
|---|---|---|---|
| GOTERM_CC_DIRECT | GO:0005576 extracellular region | 22 | 8.63×10−11 |
| GOTERM_BP_DIRECT | GO:0018149 peptide cross-linking | 7 | 5.00×10−9 |
| GOTERM_CC_DIRECT | GO:0070062 extracellular exosome | 25 | 1.27×10−8 |
| GOTERM_BP_DIRECT | GO:0030216 keratinocyte differentiation | 7 | 6.52×10−8 |
| GOTERM_CC_DIRECT | GO:0005615 extracellular space | 17 | 1.21×10−7 |
| GOTERM_BP_DIRECT | GO:0031424 keratinization | 6 | 2.16×10−7 |
| GOTERM_BP_DIRECT | GO:0016266 O-glycan processing | 6 | 6.72×10−7 |
| GOTERM_BP_DIRECT | GO:0022617 extracellular matrix disassembly | 6 | 2.20×10−6 |
| GOTERM_MF_DIRECT | GO:0005198 structural molecule activity | 8 | 3.19×10−6 |
| GOTERM_CC_DIRECT | GO:0005796 Golgi lumen | 6 | 4.70×10−6 |
| KEGG_PATHWAY | hsa00590 Arachidonic acid metabolism | 5 | 1.02×10−4 |
| KEGG_PATHWAY | hsa04610 Complement and coagulation cascades | 5 | 1.56×10−4 |
| KEGG_PATHWAY | hsa05323 Rheumatoid arthritis | 5 | 3.98×10−4 |
| KEGG_PATHWAY | hsa00982 Drug metabolism - cytochrome P450 | 4 | 0.002504 |
| KEGG_PATHWAY | hsa00980 Metabolism of xenobiotics by cytochrome P450 | 4 | 0.003187 |
| KEGG_PATHWAY | hsa00350 Tyrosine metabolism | 3 | 0.008675 |
| KEGG_PATHWAY | hsa00830 Retinol metabolism | 3 | 0.028145 |
| KEGG_PATHWAY | hsa00010 Glycolysis/Gluconeogenesis | 3 | 0.02977 |
| KEGG_PATHWAY | hsa05204 Chemical carcinogenesis | 3 | 0.041201 |
GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; _BP, biological process; _CC, cellular component; _MF, molecular function; hsa, homo sapiens.