. 2018 Sep 4;9(9):917–922. doi: 10.1021/acsmedchemlett.8b00261

Table 5. Human and Rat M₁ PAM Activities for Select Analogs 14–18.

Cpd	rat M₁ PAM EC₅₀ (μM)^a [% ach Max ± SEM]	rat M₁ pEC₅₀ (±SEM)	hum M₁ PAM EC₅₀ (μM)^a [% ACh max ± SEM]	hum M₁ pEC₅₀ (±SEM)
14a	0.04, [87 ± 0]	7.41 ± 0.06	0.06, [83 ± 3]	7.22 ± 0.10
14c	0.10, [90 ± 1]	7.00 ± 0.03	0.09, [80 ± 8]	7.05 ± 0.20
15a	0.18, [87 ± 1]	6.74 ± 0.03	0.18, [84 ± 2]	6.74 ± 0.10
15b	0.10, [87 ± 1]	7.02 ± 0.04	0.12, [79 ± 4]	6.91 ± 0.10
16	0.56, [89 ± 1]	6.25 ± 0.05	0.66, [87 ± 3]	6.18 ± 0.10
18c	0.23, [93 ± 0]	6.64 ± 0.07	0.32, [84 ± 7]	6.49 ± 0.05

Calcium mobilization assays with rM₁-CHO or hM₁-CHO cells performed in the presence of an EC₂₀ fixed concentration of acetylcholine for PAM; values represent means from three (n = 3) independent experiments performed in triplicate.

Table 5. Human and Rat M1 PAM Activities for Select Analogs 14–18.

Table 5. Human and Rat M₁ PAM Activities for Select Analogs 14–18.