Table 1. SAR of the Aniline Ring^a.

Compd	R′	EC50 (μM)b	Rel. Act. (%)c
1	3′-Cl	9.7 ± 1.16	96 ± 13.9
2	H	—	47 ± 13.6
3	3′-Me	16.4 ± 0.35	96 ± 2.1
4	3′-Br	7.1 ± 1.93	87 ± 12.5
5	3′-OMe	—	38 ± 8.5
6	3′-(1-hydroxyethyl)	—	10 ± 4.8
7	4′-Me	—	8 ± 1.4
8	4′-Br	—	16 ± 4.0
9	4′-OMe	—	19 ± 0.9
10	3′,4′-diMe	—	37 ± 11.3
11	3′,5′-diMe	—	44 ± 20.4
12	3′,4′-diCl	—	22 ± 5.6
13	3′,5′-diCl	—	41 ± 26.5
14	3′-Cl-4′-F	13.1 ± 1.20	96 ± 10.6

^aEach value represents the mean ± SD of at least two separate experiments.

^b“—” denotes an EC₅₀ value of >100 μM or an EC₅₀ value that was not calculated due to low efficacy in vitro.

^cActivation values represent the percentage activation for each compound relative to the activation of a positive control compound.^14,16,17