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Effect of neuronal activity on myelination. Model for potential mechanisms by which rhythmic stimulation could affect proliferation of OPCs, differentiation into OLs or synthesis of myelin (see Discussion for details). Colors and distribution represent mock immunohistochemistry staining (EdU = red, nuclear; Olig2 = green, nuclear; EdU+Olig2 = yellow, nuclear; CC1 = blue, cytoplasmic). Illustration modified from ref. 58.
