Table 2.
Univariate and multivariate Cox regression analyses for the disease‐free survival and overall survival of colorectal cancer patients
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Overall survival | ||||
| Age (< 60/≥ 60) | 1·121 (0·723–1·737) | 0·611 | ||
| Gender (Female/Male) | 0·693 (0·439–1·095) | 0·116 | ||
| Dukes stage (A–B/C–D) | 3·986 (2·349–6·764) | 0·000 a | 2·370 (1·189–4·721) | 0·014 a |
| Histological grade (Well‐to‐moderate/Poor) | 0·275 (0·174–0·435) | 0·000 a | 0·303 (0·179–0·514) | 0·000 a |
| Metastasis (Yes/No) | 13·797 (7·527–25·289) | 0·000 a | 4·125 (1·943–8·757) | 0·000 a |
| YAP1 score (Low/High) | 3·067 (1·961–4·798) | 0·000 a | 1·166 (0·698–1·949) | 0·558 |
| PTEN score (Low/High) | 0·625 (0·399–0·979) | 0·040 a | 0·672 (0·403–1·122) | 0·129 |
| CD33 score (Low/High) | 10·010 (4·573–21·913) | 0·000 a | 6·582 (2·481–17·460) | 0·000 a |
| Disease‐free survival | ||||
| Age (< 60/≥ 60) | 1·114 (0·724–1·713) | 0·624 | ||
| Gender (Female/Male) | 0·720 (0·461–1·125) | 0·149 | ||
| Dukes stage (A,B/C,D) | 4·445 (2·625–7·529) | 0·000 a | 2·295 (1·165–4·521) | 0·016 a |
| Histological grade (Well‐to‐moderate/Poor) | 0·297 (0·189–0·469) | 0·000 a | 0·441 (0·266–0·732) | 0·002 a |
| Metastasis (Yes/No) | 16·730 (9·082–30·816) | 0·000 a | 6·028 (2·834–12·825) | 0·000 a |
| YAP1 score (Low/High) | 3·034 (1·956–4·705) | 0·000 a | 1·166 (0·692–1·963) | 0·564 |
| PTEN score (Low/High) | 0·629 (0·405–0·978) | 0·039 a | 0·785 (0·469–1·314) | 0·358 |
| CD33 score (Low/High) | 7·950 (3·943–16·030) | 0·000 a | 4·245 (1·830–9·850) | 0·001 a |
CI, confidence interval; DFS, disease‐free survival; HR, hazard ratio; OS, overall survival; PTEN, phosphatase and tensin homologue; YAP1, Yes‐associated protein 1.
a
Significant difference.