Table 2.
Most predictive biomarkers and cluster members for plasma water T2
| Protein Name (Uniprot ID)a | % Inc. MSEa | Cluster Members |
|---|---|---|
| Hepatocyte growth factor (P14210) | 9.51 | R-spondin-2, Galectin-7 |
| Glucokinase regulatory protein (Q14397) | 9.44 | Low-density lipoprotein receptor-related protein 1 soluble, T-lymphocyte activation antigen CD86, |
| Receptor-type tyrosine-protein kinase FLT3 (P36888) | 8.34 | Complement C4bb, Discoidin domain-containing receptor 2, Serine/threonine-protein kinase PAK 6, Heterogeneous nuclear ribonucleoprotein A/B |
| Ephrin-B2 (P52799) | 7.52 | Leucine-rich repeat transmembrane protein FLRT3, Amphoterin-induced protein 2, Ephrin-A5,NT-3 growth factor receptor, Kallikrein-8, Interleukin-1 receptor type 1, Iduronate 2-sulfatase, CD109 antigen, Cell adhesion molecule 1, SLIT and NTRK-like protein 5, Ephrin type-A receptor 2, Endoglin, Interleukin-22 receptor subunit alpha-2, OX-2 membrane glycoprotein, Semaphorin-6B, Semaphorin-6A, Interferon alpha/beta receptor 1 |
| Bone sialoprotein 2 (P21815) | 5.22 | Fibrinogenb, Alpha-1-antichymotrypsin, Antithrombin-III, Endothelial cell-specific molecule 1, Serotransferrin |
| Histone-lysine N-methyl-transferase EHMT2 (Q96KQ7) | 5.13 | Metalloproteinase inhibitor 1, Metalloproteinase inhibitor 2, Delta-like protein 4 |
| Fibroblast growth factor 2 (P09038) | 5.09 | Fibroblast growth factor 4 |
aThe most predictive biomarkers are defined as those with ≥5% increase in mean squared error (MSE)
bIn a prior study, complement C4 (C4c) and fibrinogen were strongly associated with plasma water T2 [8]