Table 1.

Hemostatic alterations in patients with SCD

Increased levels	Decreased levels
Platelet activation	Factor V
Platelet aggregation	Factor XII
Phosphatidylserine-rich platelets and red blood cells	Factor IX
Thrombin-antithrombin complexes	Protein C
Prothrombin fragment F 1.2	Protein S
Plasmin-antiplasmin complexes
Fibrinogen and fibrin-fibrinogen complex
Fibrinopeptide A
D-dimer
Plasminogen activator inhibitor

Adapted from De Franceschi et al.⁴⁷