Table 2.

Severe adverse events reported with IV iron relative to any comparator (placebo, no iron, oral iron, intramuscular iron)

Severe adverse events	RR (95%)
All iron studies	1.04 (0.93-1.17)
SAE by compound
Ferric carboxymaltose	0.82 (0.64-1.06)
Ferric gluconate	1.12 (0.96-1.30)
Ferumoxytol	1.04 (0.71-1.53)
Iron dextran	1.05 (0.77-1.45)
Iron isomaltose/polymaltose	1.09 (0.43-2.80)
Iron sucrose	1.33 (0.96-1.83)
Infusion reactions	2.47 (1.43-4.28)*
Mortality	1.06 (0.81-1.39)
Infections	1.17 (0.83-1.65)
Gastrointestinal	0.55 (0.51-0.61)*

No fatal reactions or anaphylaxis reported in 103 trials composing 10 390 treated with IV iron. Adapted from Avni et al²⁶ with permission.

^*Significant.