Table 1.

Examples of recurrent AML mutations by functional group

Functional class	Specific example mutations
Signaling and kinase pathway	FLT3, KRAS, NRAS, KIT, PTPN11, and NF1
Epigenetic modifiers (DNA methylation and chromatin modification)	DNMT3A, IDH1, IDH2, TET2, ASXL1, EZH2, and MLL/KMT2A
Nucleophosmin	NPM1
Transcription factors	CEBPA, RUNX1, and GATA2
Tumor suppressors	TP53
Spliceosome complex	SRSF2, U2AF1, SF3B1, and ZRSR2
Cohesin complex*	RAD21, STAG1, STAG2, SMC1A, and SMC3

^*Not discussed in detail within the manuscript.