Table 1.

Risk of lung cancer in patients with HL according to type of treatment and smoking category

Treatment of Hodgkin disease		RR (95% CI) by smoking category (# of case patients; control patient)*
Radiation ≥5 Gy	Alkylating agents	Non-smoker, light, other†	Moderate-heavy‡
No	No	1.0§	6.0 (1.9-20.4)
Yes	No	7.2 (2.9-21.2)	20.2 (6.8-68)
No	Yes	4.3 (1.8-11.7)	16.8 (6.2-53)
Yes	Yes	7.2 (2.8-21.6)	49.1 (15.1-187)

Adapted from Travis et al.³¹

*Represents estimated tobacco smoking habit 5 years before diagnosis date of lung cancer and corresponding date in control patients, with the use of information recorded up to 1 year before these dates.

†This group includes nonsmokers, light current cigarette smokers (<1 pack per day), former cigarette smokers, smokers of cigar and pipes only, and patients from whom tobacco smoking habit was not stated.

‡Moderate (1 to 2 packs per day) and heavy (>2 packs per day) current cigarette smokers.

§Reference group.