Table 2.

Comparison of FFP and 4-factor PCCs

	FFP	4-Factor PCCs*
Coagulation factor contained	All	FII, FVII, FIX, and FX (in all preparations); PC, PS, antithrombin (in some preparations)
ABO typing	Required	Not required
Preparation time	30-60 min (requires thawing)	Minutes (reconstitution of lyophilized powder)
Administration time	Hours	15 min per 2000 IU
Initial effective volume	1000 mL	∼40 mL
Duration of action	∼6 h (dependent on half-life of coagulation factors)	∼6 h (dependent on half-life of coagulation factors)
Virus inactivated	No	Yes

IU, international units; PC, protein C; PS, protein S.

^*Beriplex N/P/Kcentra (CSL Behring), Cofact (Sanquin), Kaskadil (LFB), Octaplex (Octapharma), and Prothromplex T(otal) (Baxter).