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Dosing of a 4-factor PCC for normalization of the INR
| Pretreatment INR | 2-<4 | 4–6 | >6 |
|---|---|---|---|
| Dose of 4-factor PCC (units of FIX)/kg.bw | 25 | 35 | 50 |
| Maximum dose* (units of FIX) | 2500 | 3500 | 5000 |
Dose is based on body weight up to but not exceeding 100 kg. For patients weighing more than 100 kg, the dose should not exceed this maximum single dose.
