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. 2017 Dec 8;2017(1):595–604. doi: 10.1182/asheducation-2017.1.595

Figure 2.

Figure 2.

Derivation of a population PK model by hierarchical multivariable regression. Dots represent postinfusion plasma measurements of clotting factor activity; each different color identifies a different patient; when more than 1 time point is available for a patient, the association among them is considered in the regression model. The red dashed line represents the average regression line; the blue dotted regression lines represent the upper and lower boundaries of the regression.