Table 2.

Characteristics of TPE procedures in TMA

Frequency: Daily

Duration: Until resolution of neurologic symptoms, lactate dehydrogenase levels approaching normal, and platelet count ≥150 000/µL for 2 consecutive days. This may be followed by discontinuing therapy or weaning. See Discussion.

Volume exchanged: 1 to 1.5 plasma volumes. See Discussion.

Replacement fluid: Plasma (eg, fresh frozen plasma, thawed, plasma, frozen plasma 24 hours) with the potential exception of TMA–S pneumonia associated, in which albumin is recommended by some authors. See Discussion.