Table 2.
Systems involved in patients with an IBMFS following SCT
| System | FA | DC | DBA | SDS |
|---|---|---|---|---|
| General | Chronic GVHD | Chronic GVHD | Chronic GVHD | Chronic GVHD |
| Oncology | Head and neck SCC (tongue), vulvar SCC, PTLD, skin | Head and neck SCC (tongue), anogenital SCC, PTLD, skin | Colon, lung, stomach, osteosarcoma | |
| Skin | Basal cell carcinoma and SCC | Basal cell carcinoma and SCC | ||
| Skeletal | Osteopenia and osteoporosis | Osteopenia and osteoporosis | ||
| Eyes | Cataracts, dry eyes, retinitis, blepharitis | Cataracts, lacrimal duct stenosis | Cataracts | |
| Gonads, male | Infertility | Infertility | Infertility | Infertility |
| Gonads, female | Infertility, early menopause | Infertility, early menopause | Infertility, early menopause | Infertility, early menopause |
| Otology | Sensory hearing loss | |||
| Cardiology | Iron overload | Iron overload, hyperlipidemia | Iron overload | |
| Endocrine | Diabetes, growth hormone deficiency, hypothyroid, dyslipidemia | Hypogonadism, dyslipidemia | ||
| Gastroenterology | Poor eating | Rectal adenocarcinoma | Stomach and colon cancer | |
| Liver | Cirrhosis, fibrosis, elevated enzymes, iron overload, adenoma, hepatocellular carcinoma | Cirrhosis, fibrosis, hepatopulmonary syndrome, portal hypertension, iron overload, hepatocellular carcinoma | Iron overload | |
| Dental | Oral SCC | Oral SCC | ||
| ENT | Head and neck SCC | Head and neck SCC | ||
| Immunology | Slow immune reconstitution | Slow immune reconstitution | Slow immune reconstitution | Slow immune reconstitution |
| Lung | Bronchiolitis obliterans | Pulmonary fibrosis, pulmonary arteriovenous malformations | ||
| Vascular complications | Telangiectases and arteriovenous malformations | |||
| Psychiatry | Psychosocial issues | Psychosocial issues | Psychosocial issues | Psychosocial issues |
| Diagnostic test after SCT | Increased chromosome breakage with DEB or MMC, need to use skin fibroblasts | Genotype with nonhematopoietic tissue | Genotype with nonhematopoietic tissue | Decreased pancreatic enzymes (trypsinogen, isoamylase), genotype with nonhematopoietic tissue |