Table 3.

Patient-reported screening tools to phenotype pain in patients with SCD

Tool	Age range, y	Description	Scoring of tool
PAINReportIt60	Adults, ≥18	Electronic version of McGill	Tool asks patients to choose from 78 pain descriptors that are grouped into neuropathic, nociceptive, or other categories and the mean number of descriptors from each category is calculated
painDETECT61	Adolescents/ adults, ≥14	Cross-sectional questionnaire that elicits pain phenotype through questions targeted at pattern of pain, sensory symptoms of pain, aggravating and alleviating factors	Tool yields total score: 0-38 ≥19: definite neuropathic pain 13-18: probable neuropathic pain ≤12: no neuropathic pain
Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS)40,62	Adolescents/ adults, ≥14	Cross-sectional questionnaire of 7 items that screen for neuropathic pain	Tool yields total score: 0-24 ≥12 indicative of neuropathic pain
Neuropathic Pain Symptom Inventory (NPSI)40	Adults, ≥18	Cross-sectional questionnaire of 12 items that investigate neuropathic pain symptoms	Tool yields total score: 0-100 Higher scores indicate increased likelihood of neuropathic pain. No cutoff score established to differentiate neuropathic from nonneuropathic pain.
PROMIS: “Neuropathic Pain Quality”17	Adults, ≥18	In past 7 d: “Pain feels like pins and needles”; “Pain feels tingly”; “Pain feels stinging”; “Pain feels electrical”; “Pain feels numb”	Use HealthMeasures Scoring Service or HealthMeasures data collection tool to calculate scores. Generally, higher T-scores indicate more neuropathic pain.
PROMIS: “Nociceptive Pain Quality”17	Adults ≥18	In past 7 d: “Pain feels sore”; “Pain feels tender”; “Pain feels achy”; “Pain feels deep”	Use HealthMeasures Scoring Service or HealthMeasures data collection tool to calculate scores. Generally, higher T-scores indicate more nociceptive pain.