(b).
| ∆Associations | ∆Thigh IMAT : CSA (n = 94) | ∆Calf IMAT : CSA (n = 90) | ||
| β a (95% CI) | P value (FDR-adjusted P) | β a (95% CI) | P value (FDR-adjusted P) | |
| ∆Glucose (mmol/l) | −8.22 (−20.73, 4.28) | 0.197 (0.421) | 4.95 (−8.94, 18.84) | 0.480 (0.721) |
| ∆Insulin (pmol/l) | −437.86 (−1908.87, 1033.14) | 0.883 (0.883) | 968.92 (−359.38, 2297.22) | 0.151 (0.421) |
| ∆HOMA-IR | −15.37 (−67.12, 36.37) | 0.868 (0.883) | 30.19 (−17.42, 77.80) | 0.149 (0.421) |
| ∆Triglycerides (mmol/l) | −34.65 (−117.29, 47.98) | 0.677 (0.752) | 26.35 (−53.60, 106.31) | 0.514 (0.752) |
| ∆Total cholesterol (mmol/l) | −7.30 (−48.43, 33.83) | 0.560 (0.752) | 14.15 (−26.22, 54.52) | 0.488 (0.752) |
| ∆LDL (mmol/l) | 6.00 (−26.71, 38.71) | 0.949 (0.949) | 16.90 (−14.62, 48.42) | 0.289 (0.752) |
| ∆HDL (mmol/l) | −1.74 (−13.65, 10.18) | 0.578 (0.752) | −5.10 (−16.82, 6.62) | 0.390 (0.752) |
| ∆TC : HDL | −0.51 (−24.84, 23.83) | 0.647 (0.752) | 17.50 (−6.38, 41.39) | 0.149 (0.752) |
All estimates are adjusted for age and sex. Longitudinal analyses adjusted for age and baseline-dependent variable. aEstimates of the adjusted regression coefficient between glucose, insulin, HOMA-IR, TC, TG, LDL, HDL, and TC : HDL with thigh and calf IMAT; ∗ P values < 0.05. CI: confidence interval; HDL: high-density lipoprotein; HOMA-IR: homeostatic model assessment of insulin resistance; IMAT: intermuscular adipose tissue (standardized to cross-sectional area of the segment); LDL: low-density lipoprotein; TC: total cholesterol; TG: triglyceride.