Table 2.
Meta-analysis of KPS, side-effects and tumor-related pain.
| Meta-analysis | No. of study | Risk Ratio [%95 CI] | heterogeneity | ||||
|---|---|---|---|---|---|---|---|
| Fix-model | P value | Random-model | P value | I2(%) | P value | ||
| KPS | 6 | 1.83 [1.40, 2.39] | P < 0.00001 | 1.76 [1.35, 2.29] | P < 0.0001 | 0 | 0.46 |
| leukocytopenia | 6 | 0.78 [0.65, 0.93] | P = 0.007 | 0.76 [0.58, 0.99] | P = 0.04 | 50 | 0.07 |
| Grades III-IV leukocytopenia | 4 | 0.61 [0.33, 1.14] | P = 0.12 | 0.58 [0.23, 1.46] | P = 0.25 | 20 | 0.29 |
| nausea and vomiting | 5 | 0.68 [0.53, 0.86] | P = 0.001 | 0.68 [0.48, 0.96] | P = 0.03 | 47 | 0.11 |
| Grades III-IV nausea and vomiting | 4 | 0.34 [0.14, 0.82] | P = 0.02 | 0.44 [0.17, 1.13] | P = 0.09 | 4 | 0.37 |
| hand-foot syndrome | 3 | 0.55 [0.33, 0.91] | P = 0.02 | 0.54 [0.32, 0.91] | P = 0.02 | 0 | 0.48 |
| tumor-related pain | 2 | 1.81 [1.30, 2.54] | P = 0.0005 | 1.83 [1.31, 2.55] | P = 0.0004 | 0 | 0.73 |
| anemia | 3 | 0.79 [0.58, 1.08] | P = 0.14 | 0.80 [0.59, 1.09] | P = 0.15 | 0 | 0.83 |
| diarrhea | 5 | 0.77 [0.52, 1.15] | P = 0.21 | 0.76 [0.51, 1.14] | P = 0.19 | 0 | 0.8 |
| peripheral neurotoxicity | 3 | 0.64 [0.52, 0.80] | P < 0.0001 | 0.57 [0.23, 1.43] | P = 0.23 | 91 | <0.00001 |
| oral mucositis | 2 | 0.46 [0.25, 0.83] | P = 0.01 | 0.37 [0.04, 3.47] | P = 0.39 | 88 | 0.004 |