. Author manuscript; available in PMC: 2018 Sep 18.

Published in final edited form as: Cytokine Growth Factor Rev. 2016 Aug 25;31:61–71. doi: 10.1016/j.cytogfr.2016.08.002

Table 1.

The role of CXCL8-CXCR1/2 pathway in common cancers.

Cancer type	Function	Associated factors	Ref.
Breast cancer	Proliferation	cyclin D1, p27^Kip21	[137]
	Angiogenesis	MVD	[7,63,66]
	Metastasis	integrin 3β	[137,138]
	Chemoresistance	MRP	[10]
	CSCs activation	HER2	[64,65]
Prostate cancer	Proliferation	cyclin D1, AR, CXCR7, p53	[23,79,139,140]
	Angiogenesis	VEGF	[8,9]
	Metastasis	MMP-2/9, E-cadherin	[9,141]
	Chemoresistance	src, NF-κB, c-FLIP, Akt	[6,11,142]
Lung cancer	Proliferation	EGFR	[25]
	Angiogenesis	VEGF, MVD	[88,90,143,144]
	Metastasis	PLD, Akt, PKC, MMP-2/9,	[92,93,145,146]
Colorectal cancer	Proliferation	EGFR, MAPK	[107,147,148]
	Angiogenesis	CD31, MVD	[107,121]
	Metastasis	PI3K, Akt, Erk, integrin αvβ6	[108,149,150]
	Chemoresistance	NF-κB, Bcl-2, survivin	[151,152]
Melanoma	Proliferation	Akt, Erk	[105]
	Angiogenesis	MMP-2/9, VEGF	[99,153,154]
	Metastasis	MMP-2	[99]

MRP, Multidrug resistance protein; AR, androgen receptor; Bcl-2, B-cell CLL/lymphoma 2.