Table 2. Standardized Differences in Inattention and Hyperactivity Among in 8-Year-Old Children by Gestational Age Groups.
| Gestational Week | SD (95% CI) | |||||
|---|---|---|---|---|---|---|
| Total MoBa Samplea | Total Sibling Sampleb | Sibling Comparison Modelc | ||||
| Unadjusted | Adjusted | Unadjusted | Adjustedd | Unadjusted | Adjustedd | |
| Inattention | ||||||
| <34 | 0.33 (0.24 to 42.0) | 0.31 (0.21 to 41,0) | 0.34 (0.13 to 0.55) | 0.32 (0.12 to 52.0) | 0.31 (0.05 to 57.0) | 0.31 (0.05 to 57.0) |
| 34-36 | 0.09 (0.03 to 15.0) | 0.11 (0.05 to 17.0) | 0.08 (−0.03 to 19.0) | 0.07 (−0.03 to 17.0) | 0.03 (−0.11 to 17.0) | −0.02 (−0.16 to 12.0) |
| 37-38 | 0.01 (−0.02 to 4.0) | 0.03 (0 to 6.0) | 0.02 (−0.05 to 9.0) | 0.05 (−0.01 to 11.0) | 0.01 (−0.07 to 9.0) | 0.04 (−0.04 to 12.0) |
| 39 | −0.04 (−0.07 to −0.01) | −0.02 (−0.05 to 1.0) | 0.01 (−0.06 to 8.0) | 0.03 (−0.02 to 8.0) | 0 (−0.06 to 6.0) | 0.03 (−0.03 to 9.0) |
| 40 | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| 41 | −0.01 (−0.04 to 2.0) | −0.03 (−0.06 to 0) | 0.04 (−0.03 to 11.0) | 0.03 (−0.02 to 8.0) | 0.03 (−0.04 to 10.0) | −0.01 (−0.08 to 6.0) |
| >41 | 0.06 (0.02 to 10.0) | −0.01 (−0.05 to 3.0) | 0.11 (0.03 to 19.0) | 0.06 (−0.01 to 13.0) | 0.12 (0.02 to 22.0) | 0 (−0.10 to 10.0) |
| Hyperactivity | ||||||
| <34 | 0.23 (0.14 to 32.0) | 0.16 (0.07 to 25.0) | 0.29 (0.08 to 0.50) | 0.28 (0.07 to 49.0) | 0 (−0.28 to 28.0) | −0.03 (−0.32 to 26.0) |
| 34-36 | 0.11 (0.05 to 17.0) | 0.08 (0.02 to 14.0) | 0.09 (−0.13 to 0.31) | 0.07 (−0.04 to 18.0) | 0.05 (−0.09 to 19.0) | 0.01 (−0.13 to 15.0) |
| 37-38 | 0.01 (−0.02 to 4.0) | 0.02 (−0.01 to 5.0) | 0.05 (−0.01 to 0.11) | 0.06 (0 to 12.0) | 0.02 (−0.06 to 10.0) | 0.04 (−0.04 to 12.0) |
| 39 | −0.04 (−0.07 to −0.01) | −0.02 (−0.05 to 2.0) | 0.01 (−0.04 to 0.06) | 0.02 (−0.03 to 7.0) | 0 (−0.07 to 7.0) | 0.02 (−0.05 to 9.0) |
| 40 | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| 41 | −0.02 (−0.05 to 1.0) | −0.03 (−0.06 to 0) | 0.05 (0 to 0.10) | 0.02 (−0.03 to 7.0) | 0.05 (−0.02 to 12.0) | 0.02 (−0.05 to 9.0) |
| >41 | 0.04 (0 to 8.0) | 0 (−0.04 to 4.0) | 0.12 (0.40 to 0.20) | 0.07 (0 to 14.0) | 0.11 (0.01 to 21.0) | 0.03 (−0.07 to 13.0) |
Abbreviation: MoBa, Norwegian Mother and Child Cohort Study.
a
N = 113 227 (43 058 with outcome data).
b
n = 33 081 (13 780 With outcome data).
c
n = 24 027 Siblings discordant on exposure (9833 with inattention outcome data, 9412 with hyperactivity outcome data [discordant]). The full information maximum likelihood estimator was used for handling missing data.
d
Adjusted for pregnancy-specific characteristics: sex, small for gestational age, congenital malfunctions, parity, plurality, and bleeding before gestational week 13.