Table 2. Cross-sectional Comparisons of Baseline Best-Corrected Visual Acuity (logMAR) by Foveal Phenotype and Participant Genotype.
| Characteristic | Mean VA (logMAR) | Univariate Model | Multivariate Model | ||
|---|---|---|---|---|---|
| Difference in BCVA Compared With Reference Group (95% CI) | P Valuea | Adjusted Difference Compared With Reference Group (95% CI) | P Valuea | ||
| Fovea lesion involvement status | |||||
| No lesion (ie, normal AF) | 0.21 | 1 [Reference] | <.001 | 1 [Reference]b | <.001 |
| Increased AF | 0.62 | 0.39 (0.23 to 0.56) | 0.36 (0.17 to 0.55) | ||
| QDAF | 0.78 | 0.56 (0.48 to 0.63) | 0.47 (0.38 to 0.56) | ||
| DDAF | 0.95 | 0.63 (0.55 to 0.72) | 0.50 (0.40 to 0.60) | ||
| Genotype | |||||
| A | 0.79 | 1 [Reference] | .26 | NAc | NAc |
| B | 0.83 | 0.05 (−0.12 to 0.21) | NAc | ||
| C | 0.77 | −0.01 (−0.17 to 0.16) | NAc | ||
| D | 0.72 | −0.06 (−0.24 to 0.12) | NAc | ||
Abbreviations: AF, autofluorescence; BCVA, best-corrected visual acuity; DDAF, definitely decreased AF; NA, not applicable; QDAF, questionably decreased AF; VA, visual acuity.
a
The P value is for testing whether there was a significant difference in BCVA comparing the different groups.
b
The multivariate model adjusted for other variables that were significantly associated with baseline BCVA, including age at symptom onset, duration of symptoms, presence of retinal pigment epithelium pigmentation abnormality, and presence of flecks outside the arcade. Their associations were reported in our prior ProgStar report.4
c
Not applicable in multivariate model because the variable was not associated with baseline VA in the univariate analysis at P < .10.