Table 1. Characteristics of 29 Brand-name Combination Drugs Used in Medicare Part D in 2016.

Brand-name Combination Drug	Generic Constituents	Therapeutic Area	No. of Medicare Beneficiaries in 2016a	Change in List Price Between 2011 and 2016b
				Amount of Increase/Pill, $c	% Increased
Constituents Available as Generic Medications at Identical Doses Category
Epzicom	Abacavir, lamivudine	Infectious disease	15 713	11.43	36
Bidil	Isosorbide dinitrate, hydralazine	Cardiovascular	11 187	0.91	45
Diovan HCT	Valsartan, hydrochlorothiazide	Cardiovascular	7536	4.17	115
Pylera	Bismuth, metronidazole, tetracycline	Infectious disease	5814	2.51	75
Exforge	Amlodipine, valsartan	Cardiovascular	5036	4.29	109
Percocet	Oxycodone, acetaminophen	Pain	4097	9.58	206
Hyzaar	Losartan, hydrochlorothiazide	Cardiovascular	2902	1.25	39
Micardis HCT	Telmisartan, hydrochlorothiazide	Cardiovascular	2474	2.42	73
Lotrel	Amlodipine, benazepril	Cardiovascular	2405	3.86	87
Fosamax Plus D	Alendronate, vitamin D3	Endocrine	2068	15.28	64
Simcor	Extended-release niacin, simvastatin	Cardiovascular	1967	2.50	82
Exforge HCT	Amlodipine, valsartan, hydrochlorothiazide	Cardiovascular	1517	4.35	109
Zegerid	Omeprazole, sodium bicarbonate	Gastrointestinal	1486	78.36	989
Tarka	Trandolapril, extended-release verapamil	Cardiovascular	1365	1.10	35
Caduet	Amlodipine, atorvastatin	Cardiovascular	1219	6.21	109
Advicor	Extended-release niacin, lovastatin	Cardiovascular	1056	3.03	80
Avalide	Irbesartan, hydrochlorothiazide	Cardiovascular	1047	3.57	110
Arthrotec 75	Diclofenac, misoprostol	Pain	794	3.09	111
Actoplus Met XR	Pioglitazone, extended-release metformin	Endocrine	732	6.65	121
Stalevo 100	Carbidopa, levodopa, entacapone	Neurological	295	2.87	88
Generic Constituents at Different Doses Category
Nuedexta	Dextromethorphan, quinidine	Neurological	50 402	3.64	42
Duexis	Ibuprofen, famotidine	Pain	5907	18.65	1160
Treximet	Sumatriptan, naproxen sodium	Neurological	1878	57.60	256
Therapeutically Equivalent Generic Substitutes Category
Benicar HCT	Olmesartan, hydrochlorothiazide	Cardiovascular	158 083	3.54	106
Azor	Amlodipine, olmesartan	Cardiovascular	54 139	4.05	105
Tribenzor	Olmesartan, amlodipine, hydrochlorothiazide	Cardiovascular	32 869	4.22	105
Jalyn	Dutasteride, tamsulosin	Urological	12 920	1.86	51
Edarbyclor	Azilsartan, chlorthalidone	Cardiovascular	11 805	2.53e	90
Vimovo	Naproxen, esomeprazole	Pain	5958	28.48	1759

^aIndicates the number of unique Medicare enrollees who took this medication.

^bReported by the Centers for Medicare & Medicaid Services.

^cMean price per dosage unit (pill, tablet, or other dosage form) weighted to account for variation in claims volume for different strengths, routes, and dosage forms.

^dRounded to the nearest whole number.

^eChange in list price from 2012 to 2016.