Table 2. Multivariable Cox Regression Analysis of Risk Factors Associated With Mortality After Metastasis Diagnosis.

Risk Factor	Referent	1982-1991		1992-2001		2002-2011
		Hazard Ratio (95% CI)	P Value	Hazard Ratio (95% CI)	P Value	Hazard Ratio (95% CI)	P Value
Treatment	No metastasis treatment	0.36 (0.26-0.49)	<.001	0.33 (0.24-0.44)	<.001	0.41 (0.27-0.62)	<.001
Hepatic metastasis	Extrahepatic metastasis	2.13 (1.17-3.89)	.01	2.18 (1.31-3.61)	.003	2.27 (0.98-5.27)	.06