Table 1. Patient and Tumor Characteristics, Overall and by HPV Relatedness, SEER 2000 to 2014.
| Characteristic | Frequency, No. (%)a | ||
|---|---|---|---|
| Total (n = 109 512) |
First Potentially HPV-Associated HNSCC (n = 41 682) |
First Non–HPV-Associated HNSCC (n = 67 830) |
|
| HPV relatedness | |||
| First potentially HPV-associated HNSCC | 41 682 (38.1) | NA | NA |
| First non–HPV-associated HNSCC | 67 830 (61.9) | NA | NA |
| Anatomic sites | |||
| Oropharynx | 41 682 (38.1) | NA | NA |
| Oral cavity | 30 464 (27.8) | NA | NA |
| Larynx | 31 802 (29.0) | NA | NA |
| Hypopharynx | 5564 (5.08) | NA | NA |
| Second primary tumor | |||
| No | 95 995 (87.7) | 37 686 (90.4) | 58 309 (86.0) |
| Yes | 13 517 (12.3) | 3996 (9.6) | 9521 (14.0) |
| Age at index HNSCC diagnosis, y | |||
| ≤49 | 15 860 (14.5) | 7347 (17.6) | 8513 (12.6) |
| 50-59 | 33 049 (30.2) | 15 242 (36.6) | 17 807 (26.2) |
| 60-69 | 31 676 (28.9) | 11 887 (28.5) | 19 789 (29.2) |
| ≥70 | 28 927 (26.4) | 7206 (17.3) | 21 721 (32.0) |
| Sex | |||
| Female | 26 207 (23.9) | 8254 (19.8) | 17 953 (26.5) |
| Male | 83 305 (76.1) | 33 428 (80.2) | 49 877 (73.5) |
| Race | |||
| White | 91 699 (83.7) | 35 804 (85.9) | 55 895 (82.4) |
| Black | 12 158 (11.1) | 4009 (9.6) | 8149 (12.0) |
| Other | 5655 (5.2) | 1869 (4.5) | 3786 (5.6) |
| Marital status at HNSCC diagnosis | |||
| Married | 56 974 (52.0) | 22 835 (54.8) | 34 139 (50.3) |
| Divorced/separated | 15 187 (13.9) | 6083 (14.6) | 9104 (13.4) |
| Widowed | 10 272 (9.4) | 2671 (6.4) | 7601 (11.2) |
| Never married | 19 742 (18.0) | 7668 (18.4) | 12 074 (17.8) |
| Unknown | 7337 (6.7) | 2425 (5.8) | 4912 (7.2) |
| Year of diagnosis of first HNSCC | |||
| 2000 to 2004 | 34 224 (31.2) | 10 857 (26.0) | 23 367 (34.4) |
| 2005 to 2009 | 36 534 (33.4) | 14 157 (34.0) | 22 377 (33.0) |
| 2010 to 2014 | 38 754 (35.4) | 16 668 (40.0) | 22 086 (32.6) |
| Histologic grade | |||
| Well | 14 649 (13.4) | 2549 (6.1) | 12 100 (17.8) |
| Moderately | 45 674 (41.7) | 14 409 (34.6) | 31 265 (46.1) |
| Poor | 26 764 (24.4) | 15 056 (36.1) | 11 708 (17.3) |
| Undifferentiated/unknown | 22 425 (20.5) | 9668 (23.2) | 12 757 (18.8) |
| Stage | |||
| Localized | 41 826 (38.2) | 6137 (14.7) | 35 689 (52.6) |
| Regional | 46 322 (42.3) | 26 910 (64.6) | 19 412 (28.6) |
| Distant | 17 233 (15.7) | 7192 (17.2) | 10 041 (14.8) |
| Unstaged/unknown | 4131 (3.8) | 1443 (3.5) | 2688 (4.0) |
| Surgery performed | |||
| Yes | 54 981 (50.5) | 17 182 (41.4) | 37 799 (56.0) |
| No | 53 995 (49.5) | 2030 (58.6) | 29 720 (44.0) |
Abbreviations: HNSCC, head and neck squamous cell carcinoma; HPV, human papillomavirus; NA, not applicable; SEER, Surveillance, Epidemiology, and End Results.
a
P < .001 for all.