Table 2. Risk of Solid Tumor SPMN According to the Characteristics of the First HNSCC in 12 618 Patients, SEER 2000 to 2014.
| Characteristic | Observed | Expected | PYR | SIR Rate (95% CI) | EAR per 10 000 PYR |
|---|---|---|---|---|---|
| All HNSCC patients | 12 618 | 6519.42 | 425 793.49 | 2.18 (2.14-2.22) | 160.34 |
| HPV-relatedness | |||||
| First potentially HPV-associated HNSCC | 3996 | 2120.94 | 161 538.00 | 1.88 (1.83-1.94) | 116.08 |
| First non-HPV-associated HNSCC | 9521 | 4398.48 | 264 255.48 | 2.16 (2.12-2.21) | 193.85 |
| Anatomic sites | |||||
| Oropharynx | 3996 | 2120.94 | 161 538.00 | 1.88 (1.83-1.94) | 116.08 |
| Larynx | 4635 | 2288.18 | 129 327.93 | 2.03 (1.97-2.08) | 181.46 |
| Oral cavity | 4217 | 1875.17 | 120 792.16 | 2.25 (2.18-2.32) | 193.87 |
| Hypopharynx | 669 | 235.12 | 14 135.39 | 2.85 (2.63-3.07) | 306.95 |
| Age at index HNSCC diagnosis, y | |||||
| ≤49 | 1264 | 351.12 | 81 423.47 | 3.60 (3.40-3.80) | 112.12 |
| 50-59 | 3785 | 1523.29 | 138 734.03 | 2.48 (2.41-2.57) | 163.02 |
| 60-69 | 4606 | 2349.34 | 117 776.61 | 1.96 (1.90-2.02) | 191.61 |
| ≥70 | 3862 | 2295.67 | 87 859.39 | 1.68 (1.63-1.74) | 178.28 |
| Sex | |||||
| Male | 10 403 | 5308.88 | 326 375.27 | 1.96 (1.92-2.00) | 156.08 |
| Female | 3114 | 1210.54 | 99 418.21 | 2.57 (2.48-2.66) | 191.46 |
| Race | |||||
| White | 11 510 | 5675.76 | 366 507.63 | 2.03 (1.99-2.07) | 159.18 |
| Black | 1503 | 611.10 | 37 408.02 | 2.46 (2.34-2.59) | 238.42 |
| Other | 502 | 177.75 | 18113.23 | 2.58 (2.58-3.08) | 179.01 |
| Marital status at HNSCC diagnosis | |||||
| Married | 7528 | 3919.39 | 248 968.45 | 1.92 (1.88-1.96) | 144.94 |
| Divorced/separated/widowed | 3060 | 1362.00 | 82 461.23 | 2.25 (2.17-2.33) | 205.92 |
| Never married | 2121 | 804.02 | 66 199.91 | 2.64 (2.53-2.75) | 198.94 |
| Unknown | 808 | 434.01 | 28 163.90 | 1.86 (1.74-1.99) | 132.79 |
| Follow-up | |||||
| 2 mo to <1 y | 2369 | 1141.65 | 79 218.86 | 2.08 (1.99-2.16) | 154.93 |
| 1 y to <5 y | 6788 | 3250.73 | 216 689.35 | 2.09 (2.04-2.14) | 163.24 |
| 5 y to <10 y | 3619 | 1728.80 | 106 793.78 | 2.09 (2.03-2.16) | 176.99 |
| ≥10 y | 741 | 398.24 | 23 091.49 | 1.83 (1.73-2.00) | 148.44 |
| Year of diagnosis of first HNSCC | |||||
| 2000 to 2004 | 6445 | 3216.18 | 199 344.70 | 2.00 (1.96-2.05) | 161.97 |
| 2005 to 2009 | 4962 | 2340.54 | 157 967.48 | 2.12 (2.06-2.18) | 165.95 |
| 2010 to 2014 | 2110 | 962.70 | 68 481.31 | 2.19 (2.10-2.29) | 167.53 |
| Histologic grade | |||||
| Well | 2025 | 1077.49 | 65 905.33 | 1.88 (1.80-1.96) | 143.77 |
| Moderately | 6001 | 2664.55 | 174 807.39 | 2.25 (2.20-2.31) | 190.86 |
| Poor | 2839 | 1424.75 | 99 121.66 | 1.99 (1.92-2.07) | 142.68 |
| Undifferentiated/unknown | 2652 | 1352.64 | 85 959.10 | 1.96 (1.89-2.04) | 151.16 |
| Stage | |||||
| Localized | 6613 | 3361.49 | 199 430.93 | 1.97 (1.92-2.02) | 163.04 |
| Regional | 4968 | 2301.29 | 168 134.36 | 2.16 (2.10-2.22) | 158.61 |
| Distant | 1433 | 593.83 | 41 649.55 | 2.41 (2.29-2.54) | 201.48 |
| Unstaged/unknown | 503 | 262.81 | 16 578.65 | 1.91 (1.75-2.09) | 144.88 |
| Surgery performed | |||||
| Yes | 7567 | 3690.99 | 246 741.46 | 2.05 (2.00-2.10) | 157.09 |
| No | 5819 | 2769.61 | 175 087.55 | 2.10 (2.05-2.16) | 174.16 |
| Unknown | 131 | 58.83 | 3964.48 | 2.23 (1.86-2.64) | 182.05 |
Abbreviations: EAR, excess absolute risk; HNSCC, head and neck squamous cell carcinoma; HPV, human papillomavirus; PYR, person-year at risk; SEER, Surveillance, Epidemiology, and End Results; SIR, standardized incidence ratio; SPMN, second primary malignant neoplasm.