Table 4. Anatomic Site of SPMN According to Site of First HNSCC in 12 618 Patients, SEER 2000 to 2014.
| Site of First HNSCC | Site of SPMNa | Observed | SIR Rate (95% CI) | EAR Per 10 000 PYR |
|---|---|---|---|---|
| All HNSCC | ||||
| All solid tumors | 12 618 | 2.18 (2.14-2.22) | 160.34 | |
| Lung and bronchus | 4028 | 4.21 (4.08-4.35) | 72.15 | |
| Tongue | 919 | 16.63 (15.57-17.74) | 20.29 | |
| Gum and other mouth | 642 | 28.96 (26.77-31.29) | 14.56 | |
| Esophagus | 527 | 5.99 (5.49-6.52) | 10.31 | |
| Larynx | 403 | 5.96 (5.39-6.57) | 7.88 | |
| Pharynx | 349 | 12.87 (11.55-14.29) | 7.56 | |
| Floor of mouth | 254 | 25.62 (22.57-28.97) | 5.73 | |
| Hypopharynx | 201 | 15.68 (13.59-18.01) | 4.42 | |
| Tonsil | 199 | 6.12 (5.30-7.03) | 3.91 | |
| Thyroid | 218 | 2.99 (2.61-3.42) | 3.41 | |
| Lip | 144 | 11.14 (9.39-13.11) | 3.08 | |
| Oropharynx | 102 | 13.30 (10.84-16.14) | 2.22 | |
| Other oral cavity and pharynx | 96 | 21.35 (17.29-26.07) | 2.15 | |
| Colorectal cancer | 533 | 1.20 (1.10-1.31) | 2.09 | |
| Liver | 207 | 1.68 (1.46-1.93) | 1.98 | |
| Urinary bladder | 477 | 1.16 (1.06-1.27) | 1.53 | |
| Stomach | 169 | 1.47 (1.26-1.71) | 1.28 | |
| Salivary gland | 72 | 3.99 (3.12-5.03) | 1.27 | |
| Oropharynx | ||||
| All solid tumors | 3742 | 1.98 (1.91-2.04) | 114.48 | |
| Lung and bronchus | 1059 | 3.63 (3.41-3.85) | 47.49 | |
| Tongue | 345 | 16.18 (14.52-17.99) | 20.04 | |
| Gum and other mouth | 157 | 21.56 (18.32-25.21) | 9.27 | |
| Esophagus | 162 | 5.47 (4.66-6.38) | 8.19 | |
| Pharynx | 107 | 10.85 (8.89-13.11) | 6.01 | |
| Larynx | 92 | 3.94 (3.18-4.83) | 4.25 | |
| Floor of mouth | 67 | 18.29 (14.17-23.22) | 3.92 | |
| Tonsil | 71 | 5.11 (3.99-6.44) | 3.53 | |
| Thyroid | 81 | 2.95 (2.35-3.67) | 3.32 | |
| Hypopharynx | 50 | 11.16 (8.28-14.71) | 2.82 | |
| Oropharynx | 35 | 11.99 (8.35-16.68) | 1.99 | |
| Other oral cavity and pharynx | 28 | 17.26 (11.47-24.95) | 1.63 | |
| Nasopharynx | 22 | 8.92 (5.59-13.50) | 1.21 | |
| Oral cavity | ||||
| All solid tumors | 3903 | 2.36 (2.28-2.43) | 186.07 | |
| Lung and bronchus | 895 | 3.18 (2.98-3.40) | 50.80 | |
| Gum and other mouth | 425 | 64.35 (58.37-70.77) | 34.64 | |
| Tongue | 420 | 29.85 (27.06-32.85) | 33.61 | |
| Floor of mouth | 144 | 56.28 (47.47-66.27) | 11.71 | |
| Esophagus | 146 | 6.27 (5.29-7.37) | 10.16 | |
| Lip | 113 | 29.72 (24.50-35.74) | 9.04 | |
| Pharynx | 105 | 15.62 (12.77-18.91) | 8.14 | |
| Larynx | 101 | 6.00 (4.88-7.29) | 6.97 | |
| Tonsil | 77 | 10.23 (8.08-12.79) | 5.75 | |
| Hypopharynx | 56 | 17.70 (13.37-22.99) | 4.37 | |
| Salivary gland | 44 | 8.23 (5.98-11.05) | 3.20 | |
| Thyroid | 58 | 2.67 (2.03-3.45) | 3.00 | |
| Oropharynx | 36 | 19.47 (13.63-26.95) | 2.83 | |
| Colorectal cancer | 165 | 1.20 (1.02-1.40) | 2.26 | |
| Other oral cavity and pharynx | 27 | 23.48 (15.47-34.17) | 2.14 | |
| Liver | 52 | 1.68 (1.26-2.21) | 1.75 | |
| Larynx | ||||
| All solid tumors | 4335 | 2.13 (2.07-2.20) | 177.99 | |
| Lung and bronchus | 1804 | 5.19 (4.95-5.44) | 112.62 | |
| Larynx | 184 | 7.39 (6.36-8.54) | 12.30 | |
| Esophagus | 165 | 5.19 (4.42-6.04) | 10.30 | |
| Tongue | 125 | 6.96 (5.79-8.29) | 8.28 | |
| Pharynx | 116 | 12.20 (10.08-14.63) | 8.23 | |
| Hypopharynx | 82 | 17.53 (13.94-21.76) | 5.98 | |
| Urinary system | 312 | 1.29 (1.15-1.44) | 5.44 | |
| Urinary bladder | 216 | 1.40 (1.22-1.60) | 4.81 | |
| Thyroid | 72 | 3.37 (2.64-4.24) | 3.92 | |
| Colorectal cancer | 203 | 1.29 (1.12-1.48) | 3.55 | |
| Gum and other mouth | 49 | 6.53 (4.83-8.64) | 3.21 | |
| Liver | 81 | 1.94 (1.54-2.41) | 3.04 | |
| Other oral cavity and pharynx | 37 | 23.70 (16.68-32.67) | 2.74 | |
| Tonsil | 43 | 4.30 (3.11-5.79) | 2.55 | |
| Floor of mouth | 31 | 9.31 (6.32-13.21) | 2.14 | |
| Hypopharynx | ||||
| All solid tumors | 638 | 3.04 (2.81-3.29) | 303.08 | |
| Lung and bronchus | 270 | 7.63 (6.75-8.60) | 165.99 | |
| Esophagus | 54 | 16.72 (12.56-21.82) | 35.92 | |
| Tongue | 29 | 15.16 (10.15-21.78) | 19.16 | |
| Larynx | 26 | 10.15 (6.63-14.87) | 16.58 | |
| Pharynx | 21 | 20.38 (12.61-31.15) | 14.13 | |
| Colorectal cancer | 34 | 2.12 (1.47-2.96) | 12.68 | |
| Hypopharynx | 13 | 26.23 (13.96-44.86) | 8.85 | |
| Liver | 17 | 3.74 (2.18-5.98) | 8.81 | |
| Floor of mouth | 12 | 33.28 (17.18-58.14) | 8.23 | |
| Gum and other mouth | 11 | 14.12 (7.04-25.26) | 7.23 | |
| Stomach | 13 | 3.01 (1.60-5.14) | 6.14 | |
| Tonsil | 8 | 7.23 (3.11-14.25) | 4.88 | |
| Kidney | 14 | 1.77 (0.97-2.97) | 4.31 | |
| Oropharynx | 6 | 21.59 (7.89-47.00) | 4.05 | |
| Thyroid | 7 | 3.05 (1.22-6.28) | 3.33 | |
| Other oral cavity and pharynx | 4 | 24.51 (6.59-62.75) | 2.71 | |
| Urinary bladder | 18 | 1.22 (0.72-1.93) | 2.32 |
Abbreviations: EAR, excess absolute risk; HNSCC, head and neck squamous cell carcinoma; PYR, person-year at risk; SEER, Surveillance, Epidemiology, and End Results; SIR, standardized incidence ratio; SPMN, second primary malignant neoplasm.
a
Second primary malignant neoplasms are those with at least 1 excess case per 10 000 PYR.