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. 2018 Jun 28;4(9). doi: 10.1001/jamaoncol.2018.1812

Table 2. Dosage-Limiting Toxic Reactions Among the Dosage-Finding Cohorts.

Event Patients, No. (%)
300 mg Twice Daily (nā€‰=ā€‰8) 350 mg Twice Daily (nā€‰=ā€‰7)
Any dosage-limiting toxic reaction 1 (13) 3 (43)
Abnormal liver function test result 1 (13) 0
Drug hypersensitivity 0 1 (14)
Fatigue 0 1 (14)
Vomiting 0 1 (14)