Table. Detection of Cutavirus DNA in Primary Cutaneous B- and T-Cell Lymphomasa.
| Lymphoma Typesb | Samples Analyzed, No. | Cutavirus DNA-Positive Samples, No. (%) [95% CI] | Patients Analyzed, No.c | Cutavirus DNA-Positive Patients, No. (%) [95% CI] | Cutavirus DNA Load, Median (IQR)d |
|---|---|---|---|---|---|
| Primary cutaneous T-Cell and NK cell lymphomas | |||||
| Mycosis fungoides | 104 | 6 (5.8) [2.7-12.0] |
71 | 6 (8.5) [3.9-17.2] |
19.4 (7.5-55.6) |
| Mycosis fungoides variants and subtypes | |||||
| Folliculotropic MF | 8 | 0 | 6 | 0 | NA |
| Pagetoid reticulosis | 2 | 0 | 2 | 0 | NA |
| Sézary syndromee | 15 | 0 | 12 | 0 | NA |
| Primary cutaneous CD30-positive lymphoproliferative disorders | |||||
| Primary cutaneous anaplastic large cell lymphoma | 19 | 0 | 10 | 0 | NA |
| Lymphomatoid papulosis | 6 | 0 | 6 | 0 | NA |
| Subcutaneous panniculitis-like T-cell lymphoma | 1 | 0 | 1 | 0 | NA |
| Primary cutaneous peripheral T-cell lymphoma, not otherwise specified (NOS) | 3 | 0 | 3 | 0 | NA |
| Primary cutaneous γ/δ T-cell lymphoma | 2 | 0 | 1 | 0 | NA |
| Aggressive epidermotropic CD8-positive cytotoxic T-cell lymphoma | 1 | 0 | 1 | 0 | NA |
| Primary cutaneous CD4-positive small/medium T-cell lymphoproliferative disorder | 9 | 0 | 4 | 0 | NA |
| Primary cutaneous B-cell lymphomas | |||||
| Primary cutaneous follicle center lymphoma | 10 | 0 | 6 | 0 | NA |
| Primary cutaneous diffuse large B-cell lymphoma, leg type | 6 | 0 | 4 | 0 | NA |
| EBV-positive diffuse large B-cell lymphoma, not otherwise specified | 2 | 0 | 2 | 0 | NA |
| Primary cutaneous intravascular large B-cell lymphomae | 1 | 0 | 1 | 0 | NA |
| Total | 189 | 6 (3.2) [1.5-6.8] |
130 | 6 (4.6) [2.1-9.7] |
19.4 (7.5-55.6) |
Abbreviations: IQR, interquartile range; MF, mycosis fungoides; NA, not applicable; NK, natural killer.
Lymphoma types not available for cutavirus DNA analysis include granulomatous slack skin, adult T-cell leukemia/lymphoma (HTLV+), extranodal NK/T-cell lymphoma, nasal type, primary cutaneous acral CD8+ T-cell lymphoma, primary cutaneous marginal zone B-cell lymphoma, EBV-positive mucocutaneous ulcer, hematological neoplasms of precursor cells, and blastic plasmacytoid dendritic cell neoplasm.
According to the current World Health Organization/European Organization for Research and Treatment of Cancer classification of cutaneous lymphomas.3
Seventy-one patients were male and 59 were female; their mean age was 63.8 years (range 8-91).
Cutavirus DNA load was defined as cutavirus DNA copies per β-globin gene copy.
Entities that can present as primary cutaneous lymphomas yet often already show disseminated disease at the time of initial diagnosis.