Table 3. Impact of Test Results on Prophylactic Mastectomy Outcomes.
| Genetic Test Result | Patient Strongly Considered Prophylactic Mastectomya | Surgeon Recommended Prophylactic Mastectomya | Patient Received Prophylactic Mastectomya |
|---|---|---|---|
| BRCA1/2 pathogenic variant (n = 64) | 80.3 | 51.4 | 79.0 |
| Other pathogenic variantb (n = 24) | 39.8 | 10.3 | 37.6 |
| VUS only (n = 198) | 38.8 | 14.4 | 30.2 |
| Negative (n = 1030) | 43.7 | 14.1 | 35.3 |
Abbreviation: VUS, variant of unknown significance.
a
Weighted percent consideration, recommendation, and receipt of prophylactic mastectomy: all P < .001.
b
The other genes in which patients had pathogenic variants were APC (2), ATM (3), BARD1 (1), BRIP1 (2), CHEK2 (4), MLH1 (1), MSH6 (1), NBN (1), NF1 (1), PALB2 (3), PMS2 (2), RAD50 (1), RAD51C (2), and RAD51D (1). The total number of pathogenic variants is 25 because 1 patient had 2 pathogenic variants.