Table. Hazard Ratios (HRs) for Incident Diabetes Associated With Cancer Development in a Cohort of 494 189 Patients.
| Parameter | Person-Years | Cases, No. | Diabetes Incidence Rate, per 1000 Person-Years | Model 1a | Model 2b | Model 3c | |||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | ||||
| Cancer | |||||||||
| None | 3 445 098.6 | 25 776 | 7.5 | 1 [Reference] | <.001 | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| Incident cancer | 47 837.0 | 834 | 17.4 | 1.36 (1.27-1.46) | 1.38 (1.28-1.48) | 1.35 (1.26-1.45) | |||
| Time after cancer diagnosis, y | |||||||||
| 0 | 3 445 098.6 | 25 776 | 7.5 | 1 [Reference] | <.001 | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| <3 | 30 487.5 | 560 | 18.4 | 1.47 (1.35-1.60) | 1.48 (1.36-1.61) | 1.47 (1.35-1.60) | |||
| ≥3 to <5 | 9994.8 | 152 | 15.2 | 1.15 (0.98-1.35) | 1.16 (0.99-1.36) | 1.14 (0.97-1.33) | |||
| ≥5 | 7354.6 | 122 | 16.6 | 1.23 (1.02-1.47) | 1.25 (1.05-1.47) | 1.19 (1.00-1.43) | |||
a
Model 1: adjusted for age (20-29, 30-39, 40-49, 50-59, and 60-69 y) and sex.
b
Model 2: further adjusted for body mass index (continuous), smoking (never, former, current, and missing), and frequency of alcohol intake (<1 time per month, 1-2 times per week, 3-4 per week, almost every day, and missing).
c
Model 3: further adjusted for hypertension (yes or no), hyperlipidemia (yes or no), Charlson comorbidity index (0, 1, 2, ≥3), systolic blood pressure (continuous), fasting glucose (continuous), and total cholesterol (continuous).