Table 2. In-Hospital Mortality and Morbidity of Very Preterm Infants of Mothers With Diabetes.
Characteristic | No. (%) | OR (95% CI) | ||||
---|---|---|---|---|---|---|
Infants of Mothers With Diabetes (n = 3280) |
Infants of Mothers Without Diabetes (n = 73 080) |
Crude | Model 1 Adjusteda |
Model 2 Adjustedb |
Model 3 PS-Matchedc |
|
In-hospital mortality | 215 (6.6) | 6043 (8.3) | 0.78 (0.68-0.90) | 1.06 (0.90-1.24) | 1.16 (0.97-1.39) | 1.08 (0.88-1.32) |
In-hospital mortality or severe neonatal morbidityd | 984 (31.6) | 28 803 (40.6) | 0.67 (0.62-0.73) | 0.94 (0.86-1.03) | 0.99 (0.88-1.10) | 0.94 (0.85-1.04) |
RDS | 2165 (67.0) | 45 237 (62.4) | 1.22 (1.13-1.32) | 1.04 (0.96-1.13) | 1.01 (0.91-1.11) | 1.05 (0.95-1.17) |
IVH grade 3-4 or cPVL | 218 (6.9) | 6187 (8.7) | 0.78 (0.68-0.90) | 0.84 (0.72-0.98) | 0.91 (0.77-1.08) | 0.91 (0.75-1.12) |
Treated PDA | 766 (23.4) | 18 536 (25.4) | 0.90 (0.83-0.97) | 1.00 (0.91-1.10) | 0.98 (0.89-1.09) | 1.01 (0.91-1.13) |
Severe ROP (treated) | 157 (4.8) | 5259 (7.2) | 0.82 (0.70-0.96) | 0.93 (0.77-1.11) | 0.85 (0.69-1.03) | 1.01 (0.81-1.26) |
BPD | 611 (20.3) | 18 544 (27.9) | 0.66 (0.60-0.72) | 0.96 (0.87-1.07) | 1.01 (0.89-1.14) | 0.94 (0.83-1.06) |
NECe | 137 (5.2) | 1940 (4.2) | 1.25 (1.04-1.49) | 1.18 (0.97-1.43) | 1.18 (0.97-1.44) | 1.10 (0.84-1.43) |
Abbreviations: BPD, bronchopulmonary dysplasia; cPVL, cystic periventricular leukomalacia; IVH, intraventricular hemorrhage; N, total number in category; n, number in group; NEC, necrotizing enterocolitis; OR, odds ratio; PDA, patent ductus arteriosus; PS, propensity score; RDS, respiratory distress syndrome; ROP, retinopathy of prematurity.
Model 1 adjusted for maternal age of 35 years or older, maternal hypertensive disease in pregnancy, gestational age, sex, birth weight z score, and network.
Model 2 adjusted for the same covariates as in model 1 and antenatal corticosteroids, mode of delivery, and outborn.
Model 3: PS-matched ORs, stratified by network.
Severe neonatal morbidity defined as IVH grade 3-4, cPVL, treated ROP, or BPD.
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