Table 2. Total Participantsa and Incident Events per End Point in Each Genetic and Lifestyle Group.
| Lifestyle | Low Genetic Risk Group | Intermediate Genetic Risk Group | High Genetic Risk Group | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Ideal | Intermediate | Poor | Ideal | Intermediate | Poor | Ideal | Intermediate | Poor | |
| CAD | |||||||||
| Participants, No. | 13 648 | 49 079 | 3264 | 40 632 | 145 208 | 9869 | 13 113 | 47 144 | 3176 |
| New-onset events, No. (%) | 175 (1.3) | 1170 (2.4) | 157 (4.8) | 660 (1.6) | 4490 (3.1) | 583 (5.9) | 291 (2.2) | 2023 (4.3) | 222 (7.0) |
| IRb | 2.11 | 3.93 | 7.98 | 2.67 | 5.11 | 9.83 | 3.66 | 7.14 | 11.67 |
| PT, y | 82 942 | 297 390 | 19 681 | 247 088 | 877 887 | 59 318 | 79 520 | 283 392 | 19 022 |
| AF | |||||||||
| Participants, No. | 13 496 | 49 804 | 3466 | 41 154 | 150 668 | 10 527 | 13 302 | 47 830 | 3390 |
| New-onset events, No. (%) | 121 (0.9) | 761 (1.5) | 80 (2.3) | 544 (1.3) | 3150 (2.1) | 343 (3.3) | 301 (2.3) | 1610 (3.4) | 185 (5.5) |
| IRb | 1.47 | 2.51 | 3.76 | 2.17 | 3.44 | 5.35 | 3.74 | 5.57 | 9.06 |
| PT, y | 82 288 | 303 394 | 21 290 | 250 938 | 916 124 | 64 172 | 80 501 | 289 147 | 20 415 |
| Stroke | |||||||||
| Participants, No. | 15 135 | 55 864 | 3839 | 39 126 | 142 751 | 9803 | 13 727 | 49 325 | 3401 |
| New-onset events, No. (%) | 94 (0.6) | 491 (0.9) | 56 (1.5) | 267 (0.7) | 1368 (1.0) | 169 (1.7) | 103 (0.8) | 538 (1.1) | 59 (1.7) |
| IRb | 1.02 | 1.44 | 2.37 | 1.12 | 1.57 | 2.81 | 1.23 | 1.79 | 2.83 |
| PT, y | 92 489 | 341 153 | 23 587 | 238 912 | 872 155 | 60 196 | 83 920 | 301 334 | 20 873 |
| Hypertension | |||||||||
| Participants, No. | 11 323 | 36 193 | 2046 | 33 583 | 102 563 | 5607 | 10 666 | 31 045 | 1625 |
| New-onset events, No. (%) | 243 (2.1) | 1602 (4.4) | 167 (8.2) | 966 (2.9) | 5454 (5.3) | 552 (9.8) | 331 (3.1) | 1869 (6.0) | 174 (10.7) |
| IRb | 3.54 | 7.35 | 13.75 | 4.76 | 8.88 | 16.66 | 5.15 | 10.08 | 18.09 |
| PT, y | 68 739 | 217 818 | 12 142 | 203 145 | 614 409 | 33 136 | 64 320 | 185 346 | 9616 |
| Diabetes | |||||||||
| Participants, No. | 14 074 | 50 521 | 3439 | 40 339 | 144 261 | 9339 | 12 609 | 44 670 | 2762 |
| New-onset events, No. (%) | 38 (0.3) | 506 (1.0) | 133 (3.9) | 143 (0.4) | 2034 (1.4) | 420 (4.5) | 65 (0.5) | 887 (2.0) | 153 (5.5) |
| IRb | 0.44 | 1.64 | 6.33 | 0.58 | 2.31 | 7.4 | 0.84 | 3.26 | 9.12 |
| PT, y | 86 253 | 308 800 | 20 996 | 246 742 | 880 283 | 56 775 | 77 018 | 271 921 | 16 769 |
Abbreviations: AF, atrial fibrillation; CAD, coronary artery disease; IR, incidence rate; PT, person-time.
a
All individuals with prevalent disease were excluded per end point.
b
Incidence rates are provided per 1000 person-years.