Table 2. Significant Peak Activations Across All Reward Domains in 13 Studies.
| Region | Hemisphere | MNI Coordinates | SDM-Z Value | P Value | Voxels |
|---|---|---|---|---|---|
| ASD<TDC | |||||
| Anterior cingulate gyrus, caudate (L) | R, L | 6, 6, 20 | −2.143 | <.00005 | 197 |
| Caudate | R | 22, 24, 12 | −1.526 | <.005 | 18 |
| Central opercular cortex, insula | R | 42, −6, 18 | −1.756 | <.0005 | 80 |
| Cerebellum | R | 32, −52, −26 | −1.690 | <.001 | 23 |
| Cerebellum | L | −34, −84, −36 | −1.470 | <.005 | 13 |
| Frontal pole | R | 26, 54, −4 | −1.721 | <.0005 | 45 |
| Inferior frontal gyrus, pars triangularis | R | 34, 28, 18 | −1.547 | <.005 | 11 |
| Lateral occipital cortex (inferior) | L | −42, −86, −18 | −1.642 | <.001 | 54 |
| Middle frontal gyrus | R | 24, 14, 34 | −1.678 | <.001 | 61 |
| Nucleus accumbens, subcallosal cortex | L | −2, 6, −10 | −1.630 | <.001 | 24 |
| Occipital fusiform gyrus, occipital pole, cerebellum | L | −10, −88, −28 | −1.772 | <.0005 | 58 |
| Occipital pole, lingual gyrus, cerebellum | R | 2, −90, −20 | −1.722 | <.0005 | 237 |
| Parietal operculum cortex | R | 30, −40, 16 | −1.569 | <.005 | 10 |
| Precentral gyrus | R | 52, −2, 30 | −1.954 | <.0005 | 149 |
| Precentral gyrus | L | −58, −4, 36 | −1.674 | <.001 | 16 |
| Precuneus cortex | L | −22, −42, 10 | −1.476 | <.005 | 38 |
| Subcallosal cortex | R, L | 2, 16, −6 | −1.560 | <.005 | 16 |
| Thalamus | R | 2, −26, 16 | −1.632 | <.001 | 42 |
| Thalamus | L | −12, −34, 16 | −1.605 | <.001 | 34 |
| ASD>TDC | |||||
| Anterior cingulate gyrus | R | 6, 30, 8 | 1.961 | <.005 | 11 |
| Frontal pole | L | −22, 52, 18 | 2.236 | <.0005 | 136 |
| Insula | R | 34, 14, −10 | 2.086 | <.005 | 12 |
| Lateral occipital cortex (inferior) | R | 58, −66, 12 | 1.973 | <.005 | 14 |
| Lateral occipital cortex (inferior), angular gyrus | R | 52, −66, 16 | 2.090 | <.005 | 48 |
| Lateral occipital cortex (superior) | R | 16, −80, 40 | 1.998 | <.005 | 24 |
| Occipital fusiform gyrus, temporal occipital fusiform cortex | R | 36, −58, −10 | 2.197 | <.001 | 37 |
| Parahippocampal gyrus (anterior) | R | 28, −6, −30 | 2.187 | <.001 | 49 |
| Planum temporale, central opercular cortex | R | 60, −16, 10 | 2.129 | <.001 | 18 |
| Planum temporale, superior temporal gyrus | L | −56, −26, 6 | 2.083 | <.005 | 12 |
| Precuneus cortex | L | −2, −72, 42 | 1.979 | <.005 | 15 |
| Putamen, amygdala | R | 24, −2, −10 | 2.446 | <.0005 | 107 |
| Putamen, insula | L | −30, 0, 10 | 1.970 | <.005 | 13 |
| Superior frontal gyrus | L | −12, 28, 58 | 1.960 | <.005 | 10 |
| Superior temporal gyrus | L | −48, −22, −4 | 2.024 | <.005 | 13 |
| Superior temporal gyrus (posterior) | L | −36, −34, 4 | 2.100 | <.001 | 14 |
Abbreviations: ASD, autism spectrum disorder; L, left; MNI, Montreal Neurological Institute; R, right; SDM-Z, seed-based d mapping z-statistic; TDC, typically developing controls.