Figure 2.

Vaccine effectiveness estimates by sex for patient age groups. P values indicate significance of vaccine*sex interaction. ^aCovariates included in the interaction model were vaccination status (no, yes), sex (female, male), comorbidity (no, yes), province (AB, BC, ON, QC), collection interval (≤4, 5–7 days), calendar time (week of specimen collection based on cubic B-spline with 3 equal knots), season, and vaccine*sex. Abbreviations: AD, absolute difference (Δ female – male); CI, confidence interval; VE, vaccine effectiveness.