Schematic of UniChip design in general. The fluidic network includes a pair of inlet/outlet (O1/O2) for reciprocating flow input, one or more unidirectional channel network (UCN, U1, U2, …, Un), and a supporting channel network (SCN, a1, a2, …, an, and b1, b2, …, bn) including valving devices (v1 and v2). Fluid flows in UCN from inlets to outlets (Ai→Bi, i = 1, 2, …, n).