Skip to main content
. 2018 Sep 18;16(9):e2006643. doi: 10.1371/journal.pbio.2006643

Fig 3. Many potentially important genes are not being studied enough.

Fig 3

(A) Relative enrichment of the presence of genes with genetic loss-of-function (LoF) intolerance, presence of genes with GWAS traits, and the attention within publications. (B) Predicted versus actual NIH budget spending on individual genes (dots). The black line shows a lowess fit and the dashed lines show the two distinct regimes of the prediction (S1 Data). (C) Fraction of disease-linked genes with at least one experimental drug conditioned on the predicted order of discovery according to the model shown in Fig 2B. Error bars show 95% confidence intervals for the estimations. GWAS, genome-wide association study; LoF, loss-of-function; NIH, National Institutes of Health; USD, US dollar.