Table 2. Univariate and multivariate Cox regression analysis of novel biomarkers as predictor of sudden cardiac death and all-cause mortality in all patients.
| Sudden cardiac death | All-cause mortality | ||||||
|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | ||||
| n (yes/no) |
Events (yes/no) |
Hazard Ratio (95% CI) |
Hazard Ratio (95% CI) | Events (yes/no) |
Hazard Ratio (95% CI) |
Hazard Ratio (95% CI) | |
| hs-TnT ≥ 15 ng/L | 404/1541 | 27/23 | 5.0 (2.8–8.7)‡ | 2.9 (1.5–5.6)† | 109/96 | 4.9 (3.7–6.4)‡ | 2.4 (1.7–3.3)‡ |
| hs-CRP ≥ 1.73 mg/L | 585/1353 | 24/26 | 2.6 (1.5–4.5)† | 2.4 (1.3–4.4)† | 95/110 | 2.1 (1.6–2.7)‡ | 2.3 (1.7–3.1)‡ |
| BNP ≥ 88 ng/L | 536/1410 | 24/26 | 3.2 (1.8–5.5)‡ |
1.9 (1.0–3.7)* | 107/98 | 3.2 (2.4–4.2)‡ |
1.9 (1.4–2.6)‡ |
| sST2 ≥ 27.4 ng/mL | 227/1718 | 32/18 | 4.5 (2.5–8.1)‡ | 2.7 (1.4–5.1)‡ | 63/142 | 3.6 (2.7–4.9)‡ | 2.6 (1.9–3.6)‡ |
| hs-TnT < 15 ng/L and sST2 < 27.4 ng/mL | 1399/546 | 17/33 | Reference | Reference | 76/129 | Reference | Reference |
| hs-TnT ≥ 15 ng/L and sST2 < 27.4 ng/mL | 319/1626 | 15/35 | 4.2 (2.1–8.5)‡ | 2.6 (1.2–5.7)* | 66/139 | 4.2 (3.0–5.8)‡ | 2.1 (1.4–3.0)‡ |
| hs-TnT < 15 ng/L and sST2 ≥ 27.4 ng/mL | 142/1803 | 6/44 | 3.6 (1.4–9.0)† | 2.4 (0.9–6.8) | 20/185 | 2.7 (1.6–4.4)‡ | 2.1 (1.3–3.5)† |
| hs-TnT ≥ 15 ng/L and sST2 ≥ 27.4 ng/mL | 85/1860 | 12/38 | 13.8 (6.6–29.0)‡ | 6.4 (2.6–15.5)‡ | 43/182 | 11.6 (8.0–16.8)‡ | 5.6 (3.6–8.6)‡ |
Abbreviations: hs-TnT = highly sensitive troponin T, sST2 = soluble ST 2
Adjusted for age, sex, body mass index, Canadian Cardiovascular Society grading of angina pectoris, left ventricular ejection fraction, estimated glomerulus filtration rate, albumin-creatinine-ratio, glycated hemoglobin, and diabetes. Seventy patients excluded due to missing covariates.
* p<0.05
† p<0.01
‡ p<0.001