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. 2018 Sep 18;13(9):e0204159. doi: 10.1371/journal.pone.0204159

Fig 3. Cell line-specific induction of ALT characteristics after ATRX knockout.

Fig 3

(A) Representative telomere FISH images indicate the absence of ultrabright telomere DNA foci in MOG-G-UVW and SF188 ATRXKO clones. (B) Representative telomere FISH images indicate the presence of ultrabright telomeric DNA foci (arrows) in ATRXKO U-251 and UW479 clones. (C) Colocalization of ultrabright telomere DNA foci with PML was observed in ATRXKO U-251 and UW479 clones. (D) C-circles were detected in ATRXKO U-251 and UW479 clones, but not ATRXKO MOG-G-UVW and SF188 clones. A smaller input of U2-OS DNA (30 ng, compared to 150 ng) was included as a positive control.