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. 2018 Sep 18;13(9):e0204159. doi: 10.1371/journal.pone.0204159

Fig 7. ATRX knockdown induces ALT characteristics in U-251 and UW479.

Fig 7

(A) Representative telomere FISH images display ultrabright telomere DNA foci after ATRX knockdown in U-251 and UW479 (arrows), but not MOG-G-UVW and SF188. (B) A subset of telomeric foci that arise after ATRX knockdown colocalize with PML (arrows). (C) One out of three ATRX knockdown cells derived from UW479 (shATRX-90) shows c-circle positivity, while no other line with ATRX reduction consistently shows this feature. A lower input of U2-OS DNA (30 ng, compared to 150 ng) was included as a positive control.