Fig 7. Heatmap summarizing the transcripts from the normal colonic epithelium of Apc^Min/+ mice whose levels differ between tumor-bearing and tumor-free mice.

Expression analysis was carried out for transcripts of the normal colonic epithelium of Apc^Min/+ mice. The levels of these transcript populations were compared between mice bearing 1 or 2 colonic adenomas versus mice free of colonic adenomas. Analysis of differences between groups in hybridization signal was performed using EBarrays. The stringency cutoff was set at a difference of at least a factor of 2 fold and FDR of 20%. The Pde4b signal was confirmed by RT PCR analysis (Fig 9).