Skip to main content
. Author manuscript; available in PMC: 2018 Sep 18.
Published in final edited form as: Reprod Toxicol. 2017 Mar 7;69:221–229. doi: 10.1016/j.reprotox.2017.03.002

Fig. 1.

Fig. 1.

Scheme of events of epigenetic reprograming in male germ line (from [90] with modifications). Several animal transgenerational studies target the window of primordial germ cell epigenetic remodeling which includes significant erasure and reestablishment of DNA methylation profile. Spermatogenesis is another window during which epigenetic remodeling occurs throughout the reproductive life of the adult male and includes changes in DNA methylation, histone–protamine exchange and exosomal shuttling of ncRNA to mature spermatozoa in the epididymis. We hypothesize that disruption of epigenetic reprograming by dioxin and DLCs during this window may provide an epigenetic legacy of paternal exposures that are transferred to the next generation. See [90] for detailed figure legend.