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. 2018 Sep 3;7:e37429. doi: 10.7554/eLife.37429

Figure 5. An intrinsic cell cycle timer terminates limb bud outgrowth.

Figure 5.

HH20-HH24: antagonism of BMP signalling by Grem1 permits rapid mesenchyme proliferation and maintenance of the apical ectodermal ridge (purple) that permissively supports outgrowth. HH24-HH27: intrinsic rise in BMP signalling counters BMP antagonism and instructively decelerates mesenchyme proliferation rate. HH27-HH30: mesenchyme proliferation diminishes as patterning completes at HH28 and then BMP signalling inhibits FGF signalling in apical ectodermal ridge that then regresses.