Author response image 1. Paramecium proteins are highly divergent relative to their mammalian orthologs.

Percent identity between orthologs was calculated using the InParanoid tool from Cildb (Arnaiz et al., 2009, Database 2000 bap022; Arnaiz et al., 2014, Cilia 3:9; http://cildb.cgm.cnrs-gif.fr/). Dotted lines indicate the median of each distribution. Overall, Paramecium proteins share only 35% identity (median) with mammalian proteins, while mouse and human proteins share 95% identity with each other.